‘Transdermal application’ is the method of delivering substances into the body through the skin. It is used in products such as nicotine patches and pain-killing gels.
When taken orally, natural progesterone gets removed almost entirely by the liver. When applied in cream form over 90% of the progesterone content is absorbed.
Relevant articles:
>> Transdermal Creams – How they work and why
>> Doctors and Natural Progesterone