At the onset of using Natural Progesterone Cream a few women may experience an increase in “oestrogen dominance” symptoms. This is temporary and due to the Natural Progesterone waking up and making the oestrogen receptor sites more sensitive.
If experienced, reduce your cream to a tiny dot then build up gradually in the following weeks or until the symptoms subside. You may then resume normal application. There are no reported long-term side effects to using transdermal bioidentical Natural Progesterone Cream.
Oestrogen dominance can cause irregular cycles and retention of old blood. Because Natural Progesterone has a normalising effect on the menstrual cycle it can initially promote the shedding of this old blood. This shedding is desirable as old stored blood can increase the risk of endometrial cancer and endometriosis.